sigma-1 receptor antagonist 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12910	Sigma-1 receptor antagonist 1		Sigma receptor
	Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie...		Sigma receptor
T12911	Sigma-1 receptor antagonist 2		Sigma receptor
	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).		Sigma receptor
T12912	Sigma-1 receptor antagonist 3		Sigma receptor , HER
	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.		Sigma receptor , HER
T16883	Sigma-2 receptor antagonist 1		Others
	Sigma-2 receptor antagonist 1 is an antagonist of the sigma-2 (σ-2) receptor.		Others
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T78734	Sigma-1 receptor antagonist 5		Sigma receptor
	Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor...		Sigma receptor
T1865	S1RA	E-52862	Sigma receptor
	S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM).		Sigma receptor
T7488	BD1063 dhydrochloride	BD1063	Sigma receptor
	BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).		Sigma receptor
T79499	KSK68		Histamine Receptor
	KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases...		Histamine Receptor
T79500	KSK94		Histamine Receptor
	KSK94 is a specific H3 receptor antagonist that inhibits H3, sigma-1, and sigma-2 receptors , with Ki values of 7.9, 2958, and 75.2 nM, respectively, and can be used to study injurious pain and neuropathic pain.		Histamine Receptor
T4229	S1RA hydrochloride	E-52862 hydrochloride	Sigma receptor
	S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).		Sigma receptor
T24885	Tiospirone	BMY 13859-1	Dopamine Receptor , 5-HT Receptor
	Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia.		Dopamine Receptor , 5-HT Receptor
T21788	BD 1008 dihydrobromide		Sigma receptor
	BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors.		Sigma receptor
T1740	BD-1047 dihydrobromide	BD1047.2HBr	Sigma receptor
	BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.		Sigma receptor
T22870	IPAG		Opioid Receptor
	IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.		Opioid Receptor
T5389	Volinanserin	M 100907,MDL100907	5-HT Receptor
	Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma recepto...		5-HT Receptor
T8834	EST64454 hydrochloride	EST64454	Sigma receptor
	EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.		Sigma receptor
T7352	Pridopidine	ACR16,ASP2314,FR310826	Dopamine Receptor
	Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.		Dopamine Receptor
T70809	BD 1008 Free Base
	BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of Kᵢ = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.
T71949	CM304
	CM304 is a highly selective sigma-1 receptor antagonist.